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Common side effects include headache and vomiting.

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Methylene blue is typically given by injection into a vein. It has previously been used for treating cyanide poisoning and urinary tract infections, but this use is no longer recommended.

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Specifically, it is used to treat methemoglobin levels that are greater than 30% or in which there are symptoms despite oxygen therapy. As a medication, it is mainly used to treat methemoglobinemia by chemically reducing the ferric iron in hemoglobin to ferrous iron. Methylthioninium chloride, commonly called methylene blue, is a salt used as a dye and as a medication.

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